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Esculentoside A suppresses Abeta(142)-induced neuroinflammation by down-regulating MAPKs pathways in vivo

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This complex cleaves gasdermin D (GSDMD), releasing its N-terminal fragment (N-GSDMD), which integrates into the plasma membrane to form lytic pores, causing osmotic swelling and cytolysis

In detail, TNF--induced mtDNA expression was decreased when FTO was knocked down in RA-FLSs

Redox Biol 21:101050 TeSlaa T, Ralser M, Fan J, Rabinowitz JD (2023) The pentose phosphate pathway in health and disease

The findings could lead to new therapeutic interventions